Background: There was a need of modern approaches to the management of patients with hepatitis B (HBV).

Objectives: Improving the quality of care at all levels and co-ordination between family physicians and specialists (infectiologist and gastroenterologists).

Methods: A multidisciplinary working group performed a systematic search of clinical guidelines on a management of patients with HBV. Guidelines were assessed by AGREE II. Each of the guidelines, which were taken as the prototypes were critically assessed and adapted to the national context. Two adapted clinical guidelines (for adults and children), based on strategies of evidence-based medicine, were developed. In 2016, medical standards, i.e. unified clinical protocols, have been created, and based on the recommendations of clinical guidelines.

Results: Modern evidence on effective methods of diagnosis and treatment of patients with HBV have been included in adapted clinical guidelines. Relevant unified clinical protocols on provision for minimum acceptable quality of primary and specialised medical care have been developed. These medical and technical documents are available in the Registry of medical and technological documents on medical care standardisation (http://mtd.dec.gov.ua). Local protocols and clinical pathways, tailored to the resources of health care institutions, are being created.

Conclusions: The methodological approach to the creation of modern medical and technological documents in Ukraine allow, adapting international medical standards and creating effective tools for the management of patients with the specific diseases.
Well-coordinated work of healthcare institutions at different levels would save resources and improve healthcare.